Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5614303 | 0.85 | NAMPT (0.58) | NAMPTSMN1; SMN2PKMNPC1ALDH1A1 | |
| SCHEMBL774992 | 0.80 | NAMPT (0.52) | NAMPTSMN1; SMN2PKMALDH1A1KMT2A | |
| SCHEMBL11087591 | 0.76 | NAMPT (0.65) | NAMPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL16227562 | 0.76 | NAMPT (0.64) | NAMPTSMN1; SMN2NPC1ALDH1A1CYP19A1 | |
| SCHEMBL21098369 | 0.74 | SMN1; SMN2 (0.89) | SMN1; SMN2NPC1ALDH1A1KMT2ACYP19A1 | |
| SCHEMBL12330491 | 0.74 | MEN1 (0.70) | NAMPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL13211944 | 0.74 | SMN1; SMN2 (0.78) | NAMPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL4770380 | 0.74 | SMN1; SMN2 (0.78) | SMN1; SMN2NPC1ALDH1A1KMT2ACYP19A1 | |
| SCHEMBL6398857 | 0.74 | L3MBTL1 (0.68) | NAMPTSMN1; SMN2NPC1ALDH1A1KMT2A | |
| SCHEMBL9906905 | 0.73 | MEN1 (0.65) | NAMPTSMN1; SMN2NPC1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |