Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.42 |
| ▸ | HPGD | P15428 | 7/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.32 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.32 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.32 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 2/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23363867 | 1.00 | KDM4E (0.42) | KDM4EHPGDNPSR1MAPK1ALDH1A1 | |
| SCHEMBL25218603 | 0.88 | HPGD (0.38) | KDM4EHPGDNPSR1MAPK1ALDH1A1 | |
| SCHEMBL30460367 | 0.88 | KDM4E (0.32) | KDM4EHPGD | |
| SCHEMBL30460355 | 0.88 | KDM4E (0.32) | KDM4EHPGD | |
| SCHEMBL30460617 | 0.88 | KDM4E (0.32) | KDM4EHPGD | |
| SCHEMBL25064015 | 0.88 | KDM4E (0.32) | KDM4EHPGD | |
| SCHEMBL25064016 | 0.88 | KDM4E (0.32) | KDM4EHPGD | |
| SCHEMBL25064026 | 0.88 | KDM4E (0.32) | KDM4EHPGD | |
| SCHEMBL25064008 | 0.84 | KDM4E (0.33) | KDM4EHPGD | |
| SCHEMBL30364100 | 0.84 | KDM4E (0.33) | KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4340883-A1 | COMBINATION THERAPY | GENENTECH, INC. (US) | 2024-03-27 | — | — | EP | disclosed |
| CN-117337193-A | combination therapy | 基因泰克公司 | 2024-01-02 | — | — | CN | disclosed |
| CN-116234797-A | Heterocyclic inhibitors of TEAD for the treatment of cancer | 基因泰克公司 | 2023-06-06 | — | — | CN | disclosed |
| EP-4185386-A1 | HETEROCYCLIC INHIBITORS OF TEAD FOR TREATING CANCER | Genentech, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |
| WO-2022246459-A9 | COMBINATION THERAPY | GENENTECH, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2022246459-A1 | COMBINATION THERAPY | GENENTECH, INC. (US) | 2022-11-24 | — | — | WO | disclosed |
| EP-4058435-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2022-09-21 | — | — | EP | disclosed |