Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.30 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.30 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.30 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25064015 | 1.00 | KDM4E (0.32) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL25064026 | 1.00 | KDM4E (0.32) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL30460355 | 1.00 | KDM4E (0.32) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL30460617 | 1.00 | KDM4E (0.32) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL25064016 | 1.00 | KDM4E (0.32) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL23363867 | 0.88 | KDM4E (0.42) | KDM4EHPGD | |
| SCHEMBL29934754 | 0.88 | KDM4E (0.42) | KDM4EHPGD | |
| SCHEMBL23363723 | 0.83 | SLC5A2 (0.33) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL29934758 | 0.83 | SLC5A2 (0.33) | KDM4EHPGDTEAD1TEAD4TEAD2 | |
| SCHEMBL25064157 | 0.83 | ALDH1A1 (0.38) | KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4185386-B1 | HETEROCYCLIC INHIBITORS OF TEAD FOR TREATING CANCER | GENENTECH INC (US) | 2025-01-08 | — | — | EP | disclosed |
| EP-4185386-A1 | HETEROCYCLIC INHIBITORS OF TEAD FOR TREATING CANCER | Genentech, Inc. (US) | 2023-05-31 | — | — | EP | disclosed |