Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 4/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 3/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.41 |
| ▸ | CLK2 | P49760 | 2/20 | 0.41 |
| ▸ | CLK3 | P49761 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | PIM1 | P11309 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 2/20 | 0.41 |
| ▸ | GAK | O14976 | 1/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993535 | 1.00 | CLK1 (0.41) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2985291 | 0.91 | CISD1 (0.40) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2993707 | 0.91 | CISD1 (0.40) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2993709 | 0.91 | CISD1 (0.40) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2985295 | 0.91 | CISD1 (0.40) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL4586141 | 0.89 | PIK3CA (0.48) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2991896 | 0.89 | MEN1 (0.47) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2996253 | 0.89 | CISD1 (0.41) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2991901 | 0.89 | MEN1 (0.47) | CLK1DYRK1ADYRK1BDYRK3DYRK2 | |
| SCHEMBL2981460 | 0.89 | CISD1 (0.39) | CLK1DYRK1ADYRK1BDYRK3DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | claimed |
| US-20100184774-A1 | METHODS OF TREATMENT | SMITHKLINE BEECHAM CORPORATION | 2010-07-22 | — | — | US | disclosed |
| US-20080214455-A1 | Novel Chemical Compounds | SMITHKLINE BEECHAM CORPORATION | 2008-09-04 | — | — | US | disclosed |
| EP-1879563-A4 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-07-16 | — | — | EP | disclosed |
| EP-1879563-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006132739-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214455-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | CLK1 1393/4885DYRK1A 1531/4885DYRK1B 1810/4885 |
| US-20100184774-A1 | METHODS OF TREATMENT | OPRL1, BRCA1, PKD1 | CLK1 4211/4885DYRK1A 2870/4885DYRK1B 2344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.