Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 15/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.48 |
| ▸ | RORA | P35398 | 3/20 | 0.48 |
| ▸ | RORB | Q92753 | 3/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29935333 | 0.92 | CYP11B1 (0.57) | RORCNR1I2NR1H2NR1H3CYP11B1 | |
| SCHEMBL29935740 | 0.81 | NR1H3 (0.46) | RORCNR1H2NR1H3KMT2AMEN1 | |
| SCHEMBL29935349 | 0.79 | RORC (0.52) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL29935384 | 0.78 | RORC (0.47) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL4560780 | 0.77 | RORC (0.61) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL29935509 | 0.76 | CYP11B1 (0.49) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL29935547 | 0.75 | RORC (0.51) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL772020 | 0.74 | RORC (0.61) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL10282615 | 0.74 | RORC (0.61) | RORCNR1I2NR1H2NR1H3RORA | |
| SCHEMBL723598 | 0.72 | RORC (0.52) | RORCNR1I2NR1H2NR1H3RORA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107021923-B | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-09-23 | — | — | CN | disclosed |