Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | RORA | P35398 | 1/20 | 0.43 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28843138 | 1.00 | RORC (0.55) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL18392354 | 0.75 | MCL1 (0.76) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL28846436 | 0.73 | KMT2A (0.83) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL29817602 | 0.73 | KMT2A (0.83) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL28843212 | 0.72 | RORC (0.53) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL23884852 | 0.72 | RORC (0.58) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL4560780 | 0.72 | RORC (0.61) | RORCNR1H3NR1I2NR1H2KMT2A | |
| SCHEMBL29935333 | 0.72 | CYP11B1 (0.57) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL4537363 | 0.71 | TP53 (0.57) | RORCNR1H3NR1I2NR1H2TP53 | |
| SCHEMBL25442265 | 0.71 | RORC (0.57) | RORCNR1H3NR1I2NR1H2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107021923-B | Tetrahydroquinoline related bicyclic compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2022-09-23 | — | — | CN | disclosed |