Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | MLNR | O43193 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2993590 | 1.00 | HPGDS (0.61) | HPGDSMAPK14CYP2C9MAPK11GABRA5 | |
| SCHEMBL2986273 | 0.84 | HPGDS (0.61) | HPGDSMAPK14CYP2C9MAPK11GABRA5 | |
| SCHEMBL16495455 | 0.83 | HPGDS (0.54) | HPGDSGABRA5MLNR | |
| SCHEMBL2994352 | 0.83 | HPGDS (0.65) | HPGDSGABRA5MAP4K4 | |
| SCHEMBL2994357 | 0.83 | HPGDS (0.65) | HPGDSGABRA5MAP4K4 | |
| SCHEMBL2994776 | 0.81 | HPGDS (0.63) | HPGDSGABRA5MAP4K4 | |
| SCHEMBL2994773 | 0.81 | HPGDS (0.63) | HPGDSGABRA5MAP4K4 | |
| SCHEMBL2981040 | 0.80 | HPGDS (0.66) | HPGDSGABRA5DRD2DRD4USP30 | |
| SCHEMBL2981036 | 0.80 | HPGDS (0.66) | HPGDSGABRA5DRD2DRD4USP30 | |
| SCHEMBL2071480 | 0.80 | HPGDS (0.76) | HPGDSGABRA5DRD2DRD4USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | PFIZER INC | 2010-07-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173888-A1 | Nicotinamide Derivatives | NNT, NAMPT, NQO1 | HPGDS 1073/4885MAPK14 2795/4885CYP2C9 405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.