Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.35 |
| ▸ | NOS2 | P35228 | 2/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26697653 | 1.00 | NOS3 (0.35) | NOS3NOS2NOS1USP7 | |
| SCHEMBL14047184 | 0.77 | NOS3 (0.38) | NOS3NOS2NOS1USP7 | |
| SCHEMBL2222027 | 0.77 | NOS3 (0.38) | NOS3NOS2NOS1USP7 | |
| SCHEMBL2220883 | 0.74 | PLAU (0.39) | NOS3NOS2NOS1USP7 | |
| SCHEMBL9938335 | 0.74 | — | — | |
| SCHEMBL25194457 | 0.74 | HTT (0.40) | NOS3NOS2NOS1USP7 | |
| SCHEMBL30457008 | 0.74 | HTT (0.40) | NOS3NOS2NOS1USP7 | |
| SCHEMBL29935853 | 0.74 | — | — | |
| SCHEMBL20822293 | 0.72 | NOS3 (0.46) | NOS3NOS2NOS1USP7 | |
| SCHEMBL29936876 | 0.71 | HPGD (0.34) | NOS3NOS2NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323356-A1 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | Nuvalent, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221227-A9 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | NUVALENT, INC. (US) | 2023-11-30 | — | — | WO | disclosed |
| WO-2022221227-A1 | AMINO-SUBSTITUTED HETEROCYCLES FOR TREATING CANCERS WITH EGFR MUTATIONS | NUVALENT, INC. (US) | 2022-10-20 | — | — | WO | disclosed |