Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | PRKCI | P41743 | 5/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579149 | 0.78 | PDPK1 (0.37) | PDE4BPDE7APDPK1PRKCITNKS | |
| SCHEMBL358761 | 0.78 | PDPK1 (0.37) | PDE4BPDE7APDPK1PRKCITNKS | |
| SCHEMBL20659863 | 0.72 | ELANE (0.40) | ADORA2AADORA1PDE5ALMNAHTT | |
| SCHEMBL10264631 | 0.72 | PDE4B (0.36) | PDE4BPDE7APDPK1PRKCITNKS | |
| SCHEMBL23498442 | 0.71 | SMN1; SMN2 (0.35) | ADORA2AADORA1PDPK1TNKSPARP1 | |
| SCHEMBL164692 | 0.71 | MAPT (0.40) | SMN1; SMN2MAPTTSHRMAPK1RXFP1 | |
| SCHEMBL29936201 | 0.70 | PDE10A (0.50) | PDE4BPDE7A | |
| SCHEMBL23519900 | 0.70 | PDE10A (0.50) | PDE4BPDE7A | |
| SCHEMBL4715461 | 0.68 | ADORA2A (0.62) | ADORA2AADORA1PDE4BADORA2BADORA3 | |
| SCHEMBL11315499 | 0.67 | PDPK1 (0.37) | PDE4BPDE7APDPK1PRKCITNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4073073-A1 | THIENOPYRIMIDINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-10-19 | — | — | EP | disclosed |