Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 19/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23519900 | 1.00 | PDE10A (0.50) | PDE10APDE4BPDE7ANR1I2CYP3A4 | |
| SCHEMBL29723147 | 0.85 | PDE10A (0.47) | PDE10ANR1I2CYP3A4CYP2D6 | |
| SCHEMBL17946992 | 0.76 | PDE10A (0.38) | PDE10A | |
| SCHEMBL358761 | 0.75 | PDPK1 (0.37) | PDE4BPDE7A | |
| SCHEMBL5579149 | 0.75 | PDPK1 (0.37) | PDE4BPDE7A | |
| SCHEMBL29936166 | 0.70 | ADORA2A (0.37) | PDE4BPDE7A | |
| SCHEMBL29936278 | 0.69 | TKT (0.37) | PDE10A | |
| SCHEMBL23498442 | 0.69 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL23519924 | 0.69 | PDPK1 (0.46) | PDE4BPDE7A | |
| SCHEMBL275864 | 0.68 | PDE10A (1.00) | PDE10ANR1I2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4073073-A1 | THIENOPYRIMIDINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2022-10-19 | — | — | EP | disclosed |