Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29936175 | 1.00 | HCAR2 (0.40) | HCAR2DGAT1ADORA2AADORA1HPGD | |
| SCHEMBL14751074 | 1.00 | HCAR2 (0.40) | HCAR2DGAT1ADORA2AADORA1HPGD | |
| SCHEMBL18210150 | 1.00 | HCAR2 (0.40) | HCAR2DGAT1ADORA2AADORA1HPGD | |
| SCHEMBL18210148 | 1.00 | HCAR2 (0.40) | HCAR2DGAT1ADORA2AADORA1HPGD | |
| SCHEMBL29936386 | 1.00 | HCAR2 (0.40) | HCAR2DGAT1ADORA2AADORA1HPGD | |
| SCHEMBL1371873 | 0.91 | DGAT1 (0.39) | DGAT1JAK3ALDH1A1HTTNR3C1 | |
| SCHEMBL22191899 | 0.89 | HCAR2 (0.40) | HCAR2ADORA2AADORA1HPGDKDM4E | |
| SCHEMBL1370337 | 0.87 | DGAT1 (0.38) | DGAT1HPGDJAK3 | |
| SCHEMBL1372324 | 0.86 | DGAT1 (0.38) | DGAT1JAK3 | |
| SCHEMBL12145968 | 0.86 | DGAT1 (0.38) | DGAT1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288943-B1 | PYRROLO[2,3-B]PYRAZINYL ACRYLAMIDES AND EPOXIDES THEREOF AS INHIBITORS OF JANUS KINASE | PFIZER (US) | 2022-09-28 | — | — | EP | disclosed |