Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 20/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 13/20 | 0.44 |
| ▸ | CDK1 | P06493 | 7/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31590617 | 1.00 | CDK4 (0.46) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650621 | 0.88 | CDK4 (0.46) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650951 | 0.87 | CDK4 (0.44) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650543 | 0.87 | CDK4 (0.44) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650425 | 0.87 | CDK4 (0.47) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650584 | 0.85 | CDK6 (0.50) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL29936817 | 0.85 | CDK6 (0.50) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650528 | 0.83 | CDK4 (0.45) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650452 | 0.82 | CDK4 (0.54) | CDK4CDK6CCND1CCND3CDK2 | |
| SCHEMBL22650557 | 0.82 | CDK4 (0.53) | CDK4CDK6CCND1CCND3CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220296595-A1 | CDK INHIBITORS | GENENTECH, INC. | 2022-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220296595-A1 | CDK INHIBITORS | CDKL1, CDK9, CDK6 | CDK4 10/4885CDK6 3/4885CCND1 45/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.