SCHEMBL29936875

SCHEMBL29936875

COC(=O)c1c(F)cc(-c2ccc(OC)cc2)c(F)c1F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.54
KDM4E B2RXH2 2/20 0.54
CYP1A2 P05177 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
OPRD1 P41143 1/20 0.49
L3MBTL1 Q9Y468 4/20 0.46
TDP1 Q9NUW8 2/20 0.46
APP P05067 1/20 0.46
MAPT P10636 2/20 0.46
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
SMN1; SMN2 Q16637 2/20 0.44
BACE1 P56817 1/20 0.44
PRKAB2 O43741 1/20 0.43
PRKAG1 P54619 1/20 0.43
PRKAA2 P54646 1/20 0.43
PRKAA1 Q13131 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29936444 0.87 ALDH1A1 (0.50) TDP1MAPTALDH1A1HPGDSMN1; SMN2
SCHEMBL29936735 0.81 KDM4E (0.51) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL20373468 0.81 KDM4E (0.47) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL29936878 0.78 ALDH1A1 (0.50) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL17057625 0.76 CYP3A4 (0.46) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL1998427 0.75 MAPT (0.47) KDM4EL3MBTL1TDP1MAPTALDH1A1
SCHEMBL8017091 0.73 CYP3A4 (0.55) KDM4EL3MBTL1TDP1ALDH1A1HPGD
SCHEMBL6712384 0.72 CYP2C19 (0.46) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL22724715 0.72 CA1 (0.59) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL22561016 0.71 CA12 (0.52) CYP2C19KDM4ECYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115010600-B Method for synthesizing polyfluoroaryl carboxylic acid compound based on aryl fluorocarbon bond carboxylation reaction 四川大学 2023-11-17 CN disclosed
CN-115010600-A Method for synthesizing polyfluoroaryl carboxylic acid compounds based on aryl fluorocarbon bond carboxylation reaction 四川大学 2022-09-06 CN disclosed