Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19587071 | 0.82 | — | — | |
| SCHEMBL29669955 | 0.76 | RPS6KB1 (0.30) | RPS6KB1 | |
| SCHEMBL5930835 | 0.75 | RPS6KB1 (0.32) | RPS6KB1AKT1 | |
| SCHEMBL15741558 | 0.74 | RPS6KB1 (0.35) | RPS6KB1AKT1GRM4 | |
| SCHEMBL30449241 | 0.74 | RPS6KB1 (0.35) | RPS6KB1AKT1GRM4 | |
| SCHEMBL24857279 | 0.72 | RPS6KB1 (0.31) | RPS6KB1 | |
| SCHEMBL13313257 | 0.72 | ERN1 (0.37) | RPS6KB1AKT1 | |
| SCHEMBL30899507 | 0.71 | IDO1 (0.30) | — | |
| SCHEMBL13313253 | 0.69 | MAPT (0.42) | RPS6KB1GRM4 | |
| SCHEMBL24857280 | 0.69 | RPS6KB1 (0.33) | RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024157021-A1 | 5,6,8-TRIFLUOROQUINAZOLINES TO TREAT PARASITIC INFECTION | DE MONTFORT UNIVERSITY (GB) | 2024-08-02 | — | — | WO | claimed |
| WO-2024157021-A1 | 5,6,8-TRIFLUOROQUINAZOLINES TO TREAT PARASITIC INFECTION | DE MONTFORT UNIVERSITY (GB) | 2024-08-02 | — | — | WO | disclosed |
| WO-2024157021-A1 | 5,6,8-TRIFLUOROQUINAZOLINES TO TREAT PARASITIC INFECTION | DE MONTFORT UNIVERSITY (GB) | 2024-08-02 | — | — | WO | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |