Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 7/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 2/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15741558 | 1.00 | RPS6KB1 (0.35) | RPS6KB1GRM4AKT1KDM4EMPI | |
| SCHEMBL5930874 | 0.84 | RPS6KB1 (0.35) | RPS6KB1GRM4AKT1TET2CYP3A4 | |
| SCHEMBL13313254 | 0.84 | KDM4E (0.55) | RPS6KB1AKT1KDM4EMPIL3MBTL1 | |
| SCHEMBL13271230 | 0.84 | CD38 (0.33) | RPS6KB1GRM4AKT1KDM4EMPI | |
| SCHEMBL738572 | 0.79 | RPS6KB1 (0.31) | RPS6KB1GRM4AKT1EGFR | |
| SCHEMBL29638689 | 0.77 | RPS6KB1 (0.60) | RPS6KB1AKT1 | |
| SCHEMBL24857279 | 0.76 | RPS6KB1 (0.31) | RPS6KB1 | |
| SCHEMBL29936879 | 0.74 | RPS6KB1 (0.32) | RPS6KB1GRM4AKT1 | |
| SCHEMBL24857276 | 0.72 | GRM4 (0.33) | RPS6KB1GRM4CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL31727709 | 0.72 | CSNK2A1 (0.35) | RPS6KB1GRM4CSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116332948-A | Nitrogen-containing tetracyclic compound, preparation method and medicinal application thereof | 翰森生物有限责任公司 | 2023-06-27 | — | — | CN | disclosed |