⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29344157 | 1.00 | — | — | |
| SCHEMBL24802950 | 0.76 | AMY1A (0.32) | — | |
| SCHEMBL18299332 | 0.76 | IKBKB (0.37) | — | |
| SCHEMBL23562909 | 0.71 | PDPK1 (0.33) | — | |
| SCHEMBL31393082 | 0.71 | DYRK1A (0.32) | — | |
| SCHEMBL26404730 | 0.71 | AXL (0.31) | — | |
| SCHEMBL29937175 | 0.71 | AXL (0.31) | — | |
| SCHEMBL25547735 | 0.70 | DRD1 (0.33) | — | |
| SCHEMBL31393075 | 0.69 | DYRK1A (0.31) | — | |
| SCHEMBL31642307 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4713330-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED Limited (CN) | 2026-03-25 | — | — | EP | disclosed |
| WO-2024235286-A1 | TRICYCLIC COMPOUNDS AND USES THEREOF | HUTCHMED LIMITED (CN) | 2024-11-21 | — | — | WO | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |