Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | PRNP | P04156 | 5/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | NCEH1 | Q6PIU2 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380732 | 1.00 | SMN1; SMN2 (0.56) | SMN1; SMN2HPGDPRNPRXFP1LMNA | |
| SCHEMBL29625686 | 0.83 | PRNP (0.50) | SMN1; SMN2HPGDPRNPRXFP1LMNA | |
| SCHEMBL23515145 | 0.83 | PRNP (0.50) | SMN1; SMN2HPGDPRNPRXFP1LMNA | |
| SCHEMBL26622001 | 0.82 | RAB9A (0.55) | SMN1; SMN2HPGDPRNPRXFP1LMNA | |
| SCHEMBL29820187 | 0.82 | MAPT (0.63) | SMN1; SMN2HPGDRAB9AMAPTALDH1A1 | |
| SCHEMBL1446528 | 0.82 | MAPT (0.63) | SMN1; SMN2HPGDRAB9AMAPTALDH1A1 | |
| SCHEMBL15287590 | 0.81 | SMN1; SMN2 (0.36) | SMN1; SMN2HPGDPRNPRXFP1LMNA | |
| SCHEMBL12745123 | 0.81 | MAPT (0.58) | SMN1; SMN2HPGDPRNPRXFP1LMNA | |
| SCHEMBL15285233 | 0.81 | MAPT (0.47) | SMN1; SMN2HPGDRAB9AMAPTNPC1 | |
| SCHEMBL8731312 | 0.81 | NCEH1 (0.47) | SMN1; SMN2HPGDRAB9AMAPK1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118812473-A | Naphthyl-coumarin molecular probe and synthetic method and application thereof | 达州中医药职业学院 | 2024-10-22 | — | — | CN | disclosed |
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| EP-4087573-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. (US) | 2022-11-16 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |