SCHEMBL29937183

SCHEMBL29937183

COCOc1cc(Cl)c(C(F)(F)F)c(Br)c1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SOS1 Q07889 1/20 0.32
CASR P41180 1/20 0.31
TDP1 Q9NUW8 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23043217 1.00 SOS1 (0.32) SOS1CASRTDP1L3MBTL1
SCHEMBL29937196 0.79 MEN1 (0.34) TDP1
SCHEMBL31732853 0.79 TDP1 (0.31) TDP1L3MBTL1
SCHEMBL19617225 0.79 GRM5 (0.32)
SCHEMBL25180363 0.78 MAPT (0.31)
SCHEMBL31291676 0.77 GRM5 (0.35)
SCHEMBL30922441 0.76 CA1 (0.40) L3MBTL1
SCHEMBL31662216 0.76
SCHEMBL24919881 0.75 MAOB (0.45) L3MBTL1
SCHEMBL30033030 0.75 MAOB (0.45) L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025236100-A1 SUBSTITUTED HETEROCYCLIC COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF Université de Montréal (CA) 2025-11-20 WO disclosed
WO-2024138206-A1 FLUOROPYRIDOPYRIMIDINE AND FLUOROQUINAZOLINE DERIVATIES AND METHODS OF USE THEREOF FRONTIER MEDICINES CORPORATION (US) 2024-06-27 WO disclosed
WO-2023141570-A9 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS ARVINAS OPERATIONS, INC. (US) 2024-06-27 WO disclosed
EP-4322954-A1 SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT Merck Sharp & Dohme LLC (US) 2024-02-21 EP disclosed
WO-2023125627-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND APPLICATION THEREOF LYNK PHARMACEUTICALS CO., LTD. (CN) 2023-07-06 WO disclosed
WO-2023283933-A1 COMPOUNDS USEFUL AS KRAS G12D INHIBITORS SILEXON BIOTECH CO., LTD. (CN) 2023-01-19 WO disclosed
WO-2022221739-A1 SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT MERCK SHARP & DOHME CORP. (US) 2022-10-20 WO disclosed