Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 10/20 | 0.40 |
| ▸ | NOS1 | P29475 | 6/20 | 0.36 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21195949 | 0.88 | IDO1 (0.44) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL30007907 | 0.88 | IDO1 (0.44) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL21195941 | 0.79 | IDO1 (0.46) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL29804020 | 0.79 | IDO1 (0.46) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL30959639 | 0.77 | IDO1 (0.44) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL31642846 | 0.76 | IDO1 (0.43) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL21196002 | 0.76 | IDO1 (0.43) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL30187208 | 0.76 | IDO1 (0.43) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL21196238 | 0.74 | IDO1 (0.48) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL30410207 | 0.73 | IDO1 (0.47) | IDO1TDO2METAP2NOS1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4322954-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | Merck Sharp & Dohme LLC (US) | 2024-02-21 | — | — | EP | disclosed |
| WO-2022221739-A1 | SMALL MOLECULE INHIBITORS OF KRAS G12D MUTANT | MERCK SHARP & DOHME CORP. (US) | 2022-10-20 | — | — | WO | disclosed |