Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 6/20 | 0.39 |
| ▸ | NOS1 | P29475 | 6/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21195949 | 0.85 | IDO1 (0.44) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL30007907 | 0.85 | IDO1 (0.44) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL21196238 | 0.82 | IDO1 (0.48) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL31393227 | 0.80 | IDO1 (0.43) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL29937394 | 0.77 | IDO1 (0.41) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL21263644 | 0.77 | IDO1 (0.46) | IDO1TDO2METAP2NOS1CYP1A2 | |
| SCHEMBL19948646 | 0.77 | IDO1 (0.47) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL30410207 | 0.77 | IDO1 (0.47) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL21196262 | 0.76 | IDO1 (0.47) | IDO1TDO2METAP2NOS1AXL | |
| SCHEMBL29937471 | 0.76 | IDO1 (0.47) | IDO1TDO2METAP2NOS1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615847-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | Merck Sharp & Dohme LLC (US) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024103010-A1 | SMALL MOLECULE INHIBITORS OF KRAS PROTEINS | MERCK SHARP & DOHME LLC (US) | 2024-05-16 | — | — | WO | disclosed |