Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | TTR | P02766 | 1/20 | 0.67 |
| ▸ | PPOX | P50336 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ESRRA | P11474 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11247283 | 1.00 | TDP1 (0.67) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL11049633 | 0.92 | TDP1 (0.69) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL11168713 | 0.89 | TDP1 (0.68) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL8694365 | 0.89 | TDP1 (0.74) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL31009450 | 0.86 | MEN1 (0.50) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10706908 | 0.86 | TDP1 (0.74) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL24749507 | 0.86 | ALDH1A1 (0.48) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10348047 | 0.85 | TDP1 (0.70) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10594849 | 0.85 | MEN1 (0.70) | TDP1MEN1KMT2ATTRPPOX | |
| SCHEMBL10540835 | 0.85 | TDP1 (0.73) | TDP1MEN1KMT2ATTRPPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323338-A1 | TEAD INHIBITORS | Orion Corporation (FI) | 2024-02-21 | — | — | EP | disclosed |
| CN-117500786-A | TEAD inhibitors | 奥赖恩公司 | 2024-02-02 | — | — | CN | disclosed |
| WO-2022219246-A1 | TEAD INHIBITORS | ORION CORPORATION (FI) | 2022-10-20 | — | — | WO | disclosed |