Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | DAPK1 | P53355 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20190085 | 1.00 | GSK3A (0.49) | GSK3AGSK3BCTSLCTSBCTSS | |
| SCHEMBL20205183 | 0.87 | GSK3A (0.53) | GSK3AGSK3BBTKMTORSMG1 | |
| SCHEMBL20204994 | 0.83 | GSK3A (0.54) | GSK3AGSK3BSYKPIM1BTK | |
| SCHEMBL29939489 | 0.82 | GSK3A (0.49) | GSK3AGSK3BSYKPIM1BTK | |
| SCHEMBL20205219 | 0.82 | GSK3A (0.49) | GSK3AGSK3BSYKPIM1BTK | |
| SCHEMBL20189914 | 0.80 | JAK2 (0.55) | GSK3AGSK3BSYKPIM1IGF1R | |
| SCHEMBL20205173 | 0.78 | MAPK1 (0.52) | GSK3AGSK3BIRAK4 | |
| SCHEMBL29939117 | 0.78 | MAPK1 (0.52) | GSK3AGSK3BIRAK4 | |
| SCHEMBL20204972 | 0.78 | TSHR (0.51) | GSK3AGSK3BIRAK4 | |
| SCHEMBL29939856 | 0.78 | TSHR (0.51) | GSK3AGSK3BIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |