Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 4/20 | 0.49 |
| ▸ | GSK3B | P49841 | 4/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20205219 | 1.00 | GSK3A (0.49) | GSK3AGSK3BMAPK9MAPK10BTK | |
| SCHEMBL20204994 | 0.91 | GSK3A (0.54) | GSK3AGSK3BMAPK9MAPK10BTK | |
| SCHEMBL20205183 | 0.88 | GSK3A (0.53) | GSK3AGSK3BMAPK9MAPK10BTK | |
| SCHEMBL20189914 | 0.86 | JAK2 (0.55) | GSK3AGSK3BMAPK9MAPK10BTK | |
| SCHEMBL20205173 | 0.85 | MAPK1 (0.52) | GSK3AGSK3BMAPK9MAPK10LMNA | |
| SCHEMBL29939117 | 0.85 | MAPK1 (0.52) | GSK3AGSK3BMAPK9MAPK10LMNA | |
| SCHEMBL20204972 | 0.84 | TSHR (0.51) | GSK3AGSK3BLMNAHTTSMN1; SMN2 | |
| SCHEMBL29939856 | 0.84 | TSHR (0.51) | GSK3AGSK3BLMNAHTTSMN1; SMN2 | |
| SCHEMBL29939082 | 0.82 | GSK3A (0.49) | GSK3AGSK3BBTKSYKPIM1 | |
| SCHEMBL20190085 | 0.82 | GSK3A (0.49) | GSK3AGSK3BBTKSYKPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |