Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 9/20 | 0.68 |
| ▸ | DDR2 | Q16832 | 6/20 | 0.68 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.68 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.68 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.68 |
| ▸ | ABL1 | P00519 | 10/20 | 0.66 |
| ▸ | KIT | P10721 | 2/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | BCR | P11274 | 6/20 | 0.65 |
| ▸ | MUSK | O15146 | 1/20 | 0.65 |
| ▸ | CDK11B | P21127 | 1/20 | 0.65 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.65 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.65 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.60 |
| ▸ | SRC | P12931 | 1/20 | 0.57 |
| ▸ | LDLR | P01130 | 1/20 | 0.55 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27082313 | 1.00 | DDR1 (0.68) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27082304 | 0.88 | DDR1 (0.65) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL29939696 | 0.88 | DDR1 (0.65) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27081775 | 0.83 | NR2E1 (0.59) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27081838 | 0.79 | NR2E1 (0.67) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL29940228 | 0.79 | NR2E1 (0.67) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27083043 | 0.79 | DDR1 (0.54) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27081687 | 0.79 | DDR1 (0.54) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27081849 | 0.79 | NR2E1 (0.57) | DDR1DDR2NTRK3NTRK1NTRK2 | |
| SCHEMBL27081680 | 0.79 | ABL1 (0.61) | DDR1DDR2NTRK3NTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313292-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022200576-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |