Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3571209 | 1.00 | HDAC1 (0.53) | HDAC1HDAC6XIAPBIRC2CHRM4 | |
| SCHEMBL3565263 | 0.93 | HDAC6 (0.51) | HDAC1HDAC6XIAPBIRC2CHRM4 | |
| SCHEMBL846218 | 0.90 | HDAC1 (0.53) | HDAC1HDAC6CHRM4DRD2HTR7 | |
| SCHEMBL1270523 | 0.87 | CHRM4 (0.50) | HDAC1HDAC6XIAPBIRC2CHRM4 | |
| SCHEMBL29939759 | 0.87 | CHRM4 (0.50) | HDAC1HDAC6XIAPBIRC2CHRM4 | |
| SCHEMBL23063853 | 0.83 | HDAC1 (0.52) | HDAC1HDAC6UCHL1USP30KDM4E | |
| SCHEMBL1271119 | 0.83 | CHRM4 (0.48) | HDAC1HDAC6XIAPBIRC2CHRM4 | |
| SCHEMBL28834900 | 0.82 | NOTUM (0.60) | HDAC1HDAC6XIAPBIRC2KDM4E | |
| SCHEMBL14230676 | 0.82 | DRD2 (0.55) | BIRC2CHRM4DRD2HTR7ESR2 | |
| SCHEMBL28320901 | 0.81 | XIAP (0.56) | XIAPBIRC2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313292-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | Chiesi Farmaceutici S.p.A. (IT) | 2024-02-07 | — | — | EP | disclosed |
| CN-117062812-A | Indoline derivatives as DDR inhibitors | 奇斯药制品公司 | 2023-11-14 | — | — | CN | disclosed |
| WO-2022200576-A1 | INDOLINE DERIVATIVES AS DDR1 AND DDR2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2022-09-29 | — | — | WO | disclosed |