Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 14/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29302582 | 1.00 | TYK2 (0.36) | TYK2ABL1JAK2IKBKBROCK2 | |
| SCHEMBL29940513 | 0.90 | KLKB1 (0.39) | TYK2ABL1JAK2IKBKBROCK2 | |
| SCHEMBL29302546 | 0.90 | KLKB1 (0.39) | TYK2ABL1JAK2IKBKBROCK2 | |
| SCHEMBL29939911 | 0.89 | TYK2 (0.36) | TYK2ABL1JAK2IKBKBROCK2 | |
| SCHEMBL29304087 | 0.89 | TYK2 (0.36) | TYK2ABL1JAK2IKBKBROCK2 | |
| SCHEMBL29940331 | 0.87 | TYK2 (0.39) | TYK2 | |
| SCHEMBL29302548 | 0.87 | TYK2 (0.39) | TYK2 | |
| SCHEMBL29136913 | 0.83 | KLKB1 (0.39) | TYK2ABL1JAK2LRRK2KLKB1 | |
| SCHEMBL29136866 | 0.83 | KLKB1 (0.39) | TYK2ABL1JAK2LRRK2KLKB1 | |
| SCHEMBL29879507 | 0.83 | KLKB1 (0.39) | TYK2ABL1JAK2LRRK2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |