Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | G6PD | P11413 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2319530 | 1.00 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CTSBMAPTSMN1; SMN2 | |
| SCHEMBL29278033 | 0.94 | ALDH1A1 (0.50) | ALDH1A1CYP3A4CTSBMAPTSMN1; SMN2 | |
| SCHEMBL2321486 | 0.78 | ALDH1A1 (0.46) | ALDH1A1CYP3A4CTSBMAPTLMNA | |
| SCHEMBL844679 | 0.74 | MAPT (0.56) | ALDH1A1CYP3A4MAPTLMNATDP1 | |
| SCHEMBL2319887 | 0.74 | GAA (0.37) | MAPT | |
| SCHEMBL29706644 | 0.74 | ALDH1A1 (0.68) | ALDH1A1CYP3A4CTSBMAPTSMN1; SMN2 | |
| SCHEMBL2783704 | 0.74 | ALDH1A1 (0.68) | ALDH1A1CYP3A4CTSBMAPTSMN1; SMN2 | |
| SCHEMBL29277905 | 0.73 | MAPT (0.47) | ALDH1A1CYP3A4MAPTLMNAMAPK1 | |
| SCHEMBL18840406 | 0.72 | ALDH1A1 (0.43) | ALDH1A1CYP3A4CTSBMAPTSMN1; SMN2 | |
| SCHEMBL909587 | 0.72 | ALDH1A1 (1.00) | ALDH1A1CYP3A4CTSBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025099451-A1 | NEW COMPOUNDS AND METHODS | Transition Bio Limited (GB) | 2025-05-15 | — | — | WO | disclosed |
| EP-4308229-A1 | INHIBITORS OF PLASMA KALLIKREIN | Takeda Pharmaceutical Company Limited (JP) | 2024-01-24 | — | — | EP | disclosed |
| WO-2022197763-A1 | INHIBITORS OF PLASMA KALLIKREIN | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2022-09-22 | — | — | WO | disclosed |