Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22436846 | 0.84 | KMT2A (0.51) | MEN1KMT2APTPN1NPSR1THRB | |
| SCHEMBL30368678 | 0.83 | EPHX2 (0.39) | MEN1KMT2APTPN1 | |
| SCHEMBL22023023 | 0.83 | EPHX2 (0.39) | MEN1KMT2APTPN1 | |
| SCHEMBL25352291 | 0.79 | MEN1 (0.46) | MEN1KMT2APTPN1THRBHSD11B1 | |
| SCHEMBL7004816 | 0.78 | F13A1 (0.67) | MEN1KMT2AMET | |
| SCHEMBL13112929 | 0.78 | NPSR1 (0.42) | MEN1KMT2ANPSR1HSD11B1 | |
| SCHEMBL13112932 | 0.76 | MMP1 (0.39) | NPSR1MMP1MMP2MMP9MMP8 | |
| SCHEMBL4381121 | 0.75 | KMT2A (0.50) | MEN1KMT2APTPN1NPSR1THRB | |
| SCHEMBL13112931 | 0.74 | NPSR1 (0.43) | MEN1KMT2ANPSR1MMP1MMP2 | |
| SCHEMBL14472155 | 0.74 | KMT2A (0.50) | MEN1KMT2APTPN1NPSR1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2022-10-25 | — | — | US | disclosed |
| US-11447504-B2 | Macrocyclic chlorine substituted indole derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 2022-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11447504-B2 | Macrocyclic chlorine substituted indole derivatives | CCNT2, CCNL2, CCND2 | MEN1 193/4885KMT2A 364/4885PTPN1 1606/4885 |
| US-11478451-B1 | Macrocyclic chlorine substituted indole derivatives | CCNT2, CCNL2, CCND2 | MEN1 193/4885KMT2A 364/4885PTPN1 1606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.