Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | LOX | P28300 | 1/20 | 0.57 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.57 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL938454 | 1.00 | RECQL (0.57) | RECQLLOXLOXL3LOXL2HDAC4 | |
| SCHEMBL17286036 | 0.83 | RECQL (0.52) | RECQLLOXLOXL3LOXL2HDAC4 | |
| SCHEMBL23358131 | 0.80 | RECQL (0.49) | RECQLLOXLOXL3LOXL2ALDH1A1 | |
| SCHEMBL17804146 | 0.79 | RECQL (0.51) | RECQLLOXLOXL3LOXL2HDAC4 | |
| SCHEMBL23358048 | 0.79 | RECQL (0.51) | RECQLLOXLOXL3LOXL2HDAC4 | |
| SCHEMBL14613356 | 0.78 | UHRF1 (0.46) | HDAC4HDAC1HDAC6CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL11106783 | 0.77 | CHRNB2 (0.39) | RECQLCHRNB2CHRNA4ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL10393628 | 0.77 | CHRNB2 (0.39) | RECQLCHRNB2CHRNA4ALDH1A1TSHR | |
| SCHEMBL937707 | 0.77 | — | — | |
| SCHEMBL805501 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728950-B | Compounds useful as inhibitors of HELIOS proteins | 百时美施贵宝公司 | 2024-10-18 | — | — | CN | disclosed |
| EP-4061812-A1 | COMPOUNDS USEFUL AS INHIBITORS OF HELIOS PROTEIN | Bristol-Myers Squibb Company (US) | 2022-09-28 | — | — | EP | disclosed |