Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 1/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.34 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.34 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.34 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.34 |
| ▸ | GABRE | P78334 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25808937 | 1.00 | NPSR1 (0.48) | NPSR1L3MBTL1S1PR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL2183292 | 0.82 | NPSR1 (0.58) | NPSR1L3MBTL1S1PR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL25808946 | 0.79 | TDP1 (0.38) | ALDH1A1SMN1; SMN2DHFRGABRPGABRD | |
| SCHEMBL25808958 | 0.79 | GABRP (0.31) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL25808963 | 0.78 | SMN1; SMN2 (0.36) | NPSR1L3MBTL1ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL20302593 | 0.77 | NPSR1 (0.52) | NPSR1L3MBTL1S1PR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL282566 | 0.77 | POLB (0.35) | L3MBTL1ALDH1A1KDM4EGABRPGABRD | |
| SCHEMBL29452887 | 0.77 | POLB (0.35) | L3MBTL1ALDH1A1KDM4EGABRPGABRD | |
| SCHEMBL11730515 | 0.75 | NPSR1 (0.54) | NPSR1L3MBTL1S1PR4ALDH1A1SMN1; SMN2 | |
| SCHEMBL1424219 | 0.74 | NPSR1 (0.44) | NPSR1L3MBTL1S1PR4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118829631-A | Pyrazine compounds as FLT3 inhibitors | 拜欧米富士恩公司 | 2024-10-22 | — | — | CN | disclosed |
| CN-115124590-B | PROTAC compounds for targeted degradation of FLT3-ITD mutant proteins, and preparation method and application thereof | 武汉大学中南医院 | 2024-10-22 | — | — | CN | disclosed |
| CN-115124590-A | PROTAC compound for targeted degradation of FLT3-ITD mutant protein and preparation method and application thereof | 武汉大学中南医院 | 2022-09-30 | — | — | CN | disclosed |