Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9275185 | 0.95 | CHRM2 (0.70) | CHRM2SIGMAR1CYP1A2CYP2D6TSHR | |
| SCHEMBL29802812 | 0.90 | CA12 (0.64) | CHRM2SIGMAR1CYP1A2CYP2D6TSHR | |
| SCHEMBL11835637 | 0.86 | CHRM2 (0.76) | CHRM2CYP1A2CYP2D6TSHRCA12 | |
| SCHEMBL13278276 | 0.84 | CHRM2 (0.85) | CHRM2CYP1A2CYP2D6TSHRCA12 | |
| SCHEMBL30141723 | 0.84 | CHRM2 (0.92) | CHRM2CYP1A2CYP2D6TSHRCA12 | |
| SCHEMBL30141751 | 0.82 | CHRM2 (0.96) | CHRM2CYP1A2CYP2D6TSHRCA12 | |
| SCHEMBL11069595 | 0.82 | CHRM2 (0.96) | CHRM2CYP1A2CYP2D6TSHRCA12 | |
| SCHEMBL11073153 | 0.82 | CHRM2 (0.96) | CHRM2CYP1A2CYP2D6TSHRCA12 | |
| SCHEMBL11014192 | 0.80 | MEN1 (0.71) | CHRM2CYP1A2CYP2D6TSHRALDH1A1 | |
| SCHEMBL1642902 | 0.80 | CHRM2 (0.77) | CHRM2CYP1A2CYP2D6TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2023-10-03 | — | — | US | disclosed |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2022-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773064-B2 | 4-carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors | PARP1, PARP2, PARP12 | CHRM2 4764/4885SIGMAR1 4168/4885CYP1A2 1544/4885 |
| US-20220363636-A1 | 4-CARBOXAMIDO-ISOINDOLINONE DERIVATIVES AS SELECTIVE PARP-1 INHIBITORS | PARP1, PARP2, PARP12 | CHRM2 4759/4885SIGMAR1 4176/4885CYP1A2 1518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.