Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SOS1 | Q07889 | 11/20 | 0.38 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30014022 | 1.00 | TSHR (0.42) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL27349177 | 1.00 | TSHR (0.42) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL23526257 | 1.00 | TSHR (0.42) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL23526260 | 1.00 | TSHR (0.42) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| Hydrochloric Acid SCHEMBL27224396 | 0.98 | ALDH1A1 (0.43) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| Hydrochloric Acid SCHEMBL29755437 | 0.98 | ALDH1A1 (0.43) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| Hydrochloric Acid SCHEMBL27224651 | 0.98 | ALDH1A1 (0.43) | TSHRCYP1A2CYP3A4CYP2D6NFKB1 | |
| SCHEMBL23563886 | 0.86 | TSHR (0.43) | TSHRALDH1A1SOS1NISCHAR | |
| Trifluoroacetic Acid SCHEMBL31463924 | 0.85 | AR (0.39) | SOS1ARL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL31463954 | 0.85 | AR (0.39) | SOS1ARL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119039234-B | Pyridazine amide compound and preparation method and application thereof | 中国药科大学 | 2026-05-15 | — | — | CN | disclosed |
| CN-116768861-B | SOS1 protein degradation targeting chimeric and composition, preparation and application thereof | 北京福元医药股份有限公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-120485299-A | Preparation method of intermediate | 济南尚博医药股份有限公司 | 2025-08-15 | — | — | CN | disclosed |
| WO-2025137507-A1 | SOS1 INHIBITORS AND USES THEREOF | REGOR PHARMACEUTICALS, INC. (US) | 2025-06-26 | — | — | WO | disclosed |
| CN-119998264-A | Novel bicyclic heterocyclyl compounds and uses thereof | 第一药品株式会社 | 2025-05-13 | — | — | CN | disclosed |
| CN-119948027-A | SOS1 protein degradation agent and application thereof | 领泰生物医药(绍兴)有限公司 | 2025-05-06 | — | — | CN | disclosed |
| CN-119907792-A | Benzyl or thiophene methylene substituted aminoquinazoline derivatives and their use as SOS1 degradants | 领泰生物医药(绍兴)有限公司 | 2025-04-29 | — | — | CN | disclosed |
| CN-119546304-A | Salts of SOS1 inhibitors | 米拉蒂治疗公司 | 2025-02-28 | — | — | CN | disclosed |
| CN-119462626-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-119451960-A | Fused ring compound, preparation method and application thereof | 上海艾力斯医药科技股份有限公司 | 2025-02-14 | — | — | CN | disclosed |
| CN-119039237-A | Quinazolinamine compound, and preparation method and application thereof | 中国药科大学 | 2024-11-29 | — | — | CN | disclosed |
| CN-119039234-A | Pyridazine amide compound and preparation method and application thereof | 中国药科大学 | 2024-11-29 | — | — | CN | disclosed |
| CN-115135315-B | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-118974038-A | Heterocyclic compounds and methods of use | 薛定谔公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-117957226-A | Heterocyclic compounds as SOS1 inhibitors and uses thereof | 南京再明医药有限公司 | 2024-04-30 | — | — | CN | disclosed |
| WO-2024075070-A2 | NOVEL BICYCLIC HETEROCYCLYL COMPOUNDS AND USE THEREOF | 제일약품주식회사 | 2024-04-11 | — | — | WO | disclosed |
| WO-2024027762-A1 | FUSED RING COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2024-02-08 | — | — | WO | disclosed |
| CN-116768861-A | SOS1 protein degradation targeting chimeric and composition, preparation and application thereof | 北京福元医药股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| CN-115135315-A | SOS1 inhibitors | 米拉蒂治疗股份有限公司 | 2022-09-30 | — | — | CN | disclosed |