Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 5/20 | 0.75 |
| ▸ | ORAI1 | Q96D31 | 5/20 | 0.75 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | OGT | O15294 | 2/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26628290 | 1.00 | STIM1 (0.75) | STIM1ORAI1KEAP1NFE2L2NOTUM | |
| SCHEMBL26628296 | 0.86 | STIM1 (1.00) | STIM1ORAI1KEAP1NFE2L2NOTUM | |
| SCHEMBL29946096 | 0.86 | STIM1 (1.00) | STIM1ORAI1KEAP1NFE2L2NOTUM | |
| SCHEMBL29946195 | 0.80 | STIM1 (0.88) | STIM1ORAI1KEAP1NFE2L2OGT | |
| SCHEMBL26628313 | 0.80 | STIM1 (0.88) | STIM1ORAI1KEAP1NFE2L2OGT | |
| SCHEMBL29946187 | 0.78 | STIM1 (0.68) | STIM1ORAI1KEAP1NFE2L2NOTUM | |
| SCHEMBL29946184 | 0.78 | STIM1 (0.84) | STIM1ORAI1KEAP1NFE2L2HSD17B1 | |
| SCHEMBL26628279 | 0.78 | STIM1 (0.68) | STIM1ORAI1KEAP1NFE2L2NOTUM | |
| SCHEMBL26628274 | 0.78 | STIM1 (0.84) | STIM1ORAI1KEAP1NFE2L2HSD17B1 | |
| SCHEMBL29946188 | 0.77 | STIM1 (0.70) | STIM1ORAI1NOTUMOGTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4106871-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | Università degli Studi del Piemonte Orientale "Amedeo Avogadro" (IT) | 2022-12-28 | — | — | EP | claimed |
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | claimed |
| EP-4106871-B1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIV DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO (IT) | 2024-03-13 | — | — | EP | disclosed |
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | UNIVERSITÀ DEGLI STUDI DEL PIEMONTE ORIENTALE "AMEDEO AVOGADRO" (IT) | 2023-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348404-A1 | BIPHENYL COMPOUNDS AS SOCE MODULATORS, COMPOSITIONS AND USES THEREOF | ORAI1, SARAF, STIM1 | STIM1 3/4885ORAI1 1/4885KEAP1 1857/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.