Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | AOC1 | P19801 | 2/20 | 0.42 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | LATS1 | O95835 | 4/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.42 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16020337 | 0.84 | NAMPT (0.49) | NAMPTCYP3A4KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL26783635 | 0.84 | NAMPT (0.49) | NAMPTCYP3A4KDM4EL3MBTL1LATS1 | |
| SCHEMBL29529824 | 0.84 | NAMPT (0.49) | NAMPTCYP3A4KDM4EL3MBTL1LATS1 | |
| SCHEMBL13976039 | 0.83 | NAMPT (0.48) | NAMPTCYP3A4KDM4EL3MBTL1LATS1 | |
| SCHEMBL20567939 | 0.83 | NAMPT (0.48) | NAMPTCYP3A4L3MBTL1LATS1KCNA5 | |
| SCHEMBL31706439 | 0.83 | NAMPT (0.48) | NAMPTCYP3A4L3MBTL1LATS1KCNA5 | |
| SCHEMBL16181507 | 0.82 | NAMPT (0.49) | NAMPTCYP3A4KDM4EL3MBTL1LATS1 | |
| SCHEMBL28449955 | 0.81 | NAMPT (0.48) | NAMPTCYP3A4KDM4EL3MBTL1LATS1 | |
| SCHEMBL29530206 | 0.80 | NAMPT (0.46) | NAMPTCYP3A4L3MBTL1LATS1KCNA5 | |
| SCHEMBL26783636 | 0.80 | NAMPT (0.46) | NAMPTCYP3A4L3MBTL1LATS1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220305115-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES | Janssen Sciences Ireland Unlimited Company (IE) | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220305115-A1 | COMBINATION OF HEPATITIS B VIRUS (HBV) VACCINES AND PYRIDOPYRIMIDINE DERIVATIVES | HAVCR2, ENTPD5, HMGB3 | NAMPT 140/4885CYP3A4 263/4885KDM4E 2717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.