Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 8/20 | 0.63 |
| ▸ | ORAI1 | Q96D31 | 8/20 | 0.63 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.63 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.63 |
| ▸ | P2RY14 | Q15391 | 4/20 | 0.60 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.58 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | LDHA | P00338 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1430338 | 1.00 | STIM1 (0.63) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL26628305 | 0.90 | KEAP1 (0.69) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL29946136 | 0.90 | KEAP1 (0.69) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL26628324 | 0.88 | STIM1 (0.66) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL29946232 | 0.88 | STIM1 (0.66) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL1429925 | 0.87 | STIM1 (0.64) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL1427395 | 0.87 | STIM1 (0.66) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL2711661 | 0.87 | STIM1 (0.67) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL14997532 | 0.84 | KEAP1 (0.65) | STIM1ORAI1KEAP1NFE2L2P2RY14 | |
| SCHEMBL1429953 | 0.84 | STIM1 (0.62) | STIM1ORAI1KEAP1NFE2L2P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115243765-A | Biphenyl compounds as SOCE modulators, compositions and uses thereof | 皮埃蒙特阿米阿伏伽德罗东方大学 | 2022-10-25 | — | — | CN | disclosed |