Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCOLN2 | Q8IZK6 | 1/20 | 0.62 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23355006 | 0.86 | NAMPT (0.45) | MCOLN2RORCALDH1A1LMNAKDM4E | |
| SCHEMBL31036862 | 0.84 | MCOLN2 (0.63) | MCOLN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL23057083 | 0.81 | MCOLN2 (0.78) | MCOLN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL29978619 | 0.80 | MCOLN2 (0.77) | MCOLN2RORCALDH1A1LMNAKDM4E | |
| SCHEMBL23057211 | 0.77 | MCOLN2 (1.00) | MCOLN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL29947152 | 0.77 | MCOLN2 (0.51) | MCOLN2CCR2ALDH1A1LMNAKDM4E | |
| SCHEMBL23379695 | 0.76 | MCOLN3 (0.45) | MCOLN2RORCALDH1A1LMNAKDM4E | |
| SCHEMBL23355078 | 0.75 | MCOLN3 (0.51) | MCOLN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL29947304 | 0.75 | MCOLN2 (0.51) | MCOLN2CCR2ALDH1A1LMNAKDM4E | |
| SCHEMBL29947135 | 0.73 | MCOLN2 (0.48) | MCOLN2RORCALDH1A1LMNASCN8A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337206-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | Libra Therapeutics, Inc. (US) | 2024-03-20 | — | — | EP | disclosed |
| WO-2022240992-A1 | HETEROCYCLIC TRPML1 AGONISTS AND USES THEREOF | LIBRA THERAPEUTICS, INC. (US) | 2022-11-17 | — | — | WO | disclosed |