Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.31 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22555268 | 1.00 | SCN9A (0.31) | SCN9APRKCQPRKCDHRH4 | |
| SCHEMBL22555038 | 0.90 | PRKCQ (0.32) | SCN9APRKCQPRKCDHRH4 | |
| SCHEMBL22555256 | 0.88 | ERG (0.31) | HRH4 | |
| SCHEMBL22631412 | 0.83 | SCN9A (0.32) | SCN9A | |
| SCHEMBL29235089 | 0.80 | KDM4E (0.33) | — | |
| SCHEMBL26947438 | 0.80 | KRAS (0.53) | — | |
| SCHEMBL22220231 | 0.80 | KRAS (0.49) | — | |
| SCHEMBL22587002 | 0.80 | KRAS (0.35) | — | |
| SCHEMBL29947619 | 0.80 | KRAS (0.31) | — | |
| SCHEMBL29697734 | 0.80 | SMN1; SMN2 (0.35) | PRKCQ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187527-A1 | QUINAZOLINE NITRILE DERIVATIVES AS KRAS INHIBITORS | NIKANG THERAPEUTICS, INC (US) | 2022-09-09 | — | — | WO | disclosed |