Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.46 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.45 |
| ▸ | VNN1 | O95497 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.44 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.44 |
| ▸ | FEN1 | P39748 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23708084 | 0.82 | HRH3 (0.55) | HRH3KCNH2SCN9AL3MBTL3L3MBTL1 | |
| SCHEMBL21379310 | 0.82 | PLA2G1B (0.47) | SCN9AL3MBTL3L3MBTL1KMT2AVNN1 | |
| SCHEMBL21379308 | 0.82 | PLA2G1B (0.47) | SCN9AL3MBTL3L3MBTL1KMT2AVNN1 | |
| SCHEMBL21379476 | 0.82 | PLA2G1B (0.47) | SCN9AL3MBTL3L3MBTL1KMT2AVNN1 | |
| SCHEMBL29944135 | 0.81 | HRH3 (0.54) | HRH3KCNH2L3MBTL3L3MBTL1KMT2A | |
| SCHEMBL28940974 | 0.79 | KMT2A (0.52) | HRH3KCNH2SCN9AL3MBTL3L3MBTL1 | |
| SCHEMBL28292599 | 0.79 | KMT2A (0.52) | HRH3KCNH2SCN9AL3MBTL3L3MBTL1 | |
| SCHEMBL28292628 | 0.79 | KMT2A (0.52) | HRH3KCNH2SCN9AL3MBTL3L3MBTL1 | |
| SCHEMBL1972661 | 0.79 | NPC1 (0.59) | L3MBTL1KMT2ANPC1RAB9A | |
| SCHEMBL193622 | 0.79 | NPC1 (0.59) | L3MBTL1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4077282-A1 | PRMT5 INHIBITORS | Merck Sharp & Dohme LLC (US) | 2022-10-26 | — | — | EP | disclosed |