Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23424682 | 1.00 | MAPT (0.47) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL23390557 | 0.84 | MAPT (0.50) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL29948715 | 0.84 | MAPT (0.50) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL29948752 | 0.84 | MAPT (0.51) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL23424683 | 0.84 | MAPT (0.51) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL23390390 | 0.81 | TRPV4 (0.43) | TRPV4TRPM8KCNH2 | |
| SCHEMBL29948936 | 0.81 | TRPV4 (0.43) | TRPV4TRPM8KCNH2 | |
| SCHEMBL23390426 | 0.80 | MAPT (0.54) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL29948811 | 0.80 | MAPT (0.54) | MAPTHTTGAASMN1; SMN2NPSR1 | |
| SCHEMBL28865060 | 0.79 | TRPV4 (0.40) | MAPTALDH1A1TRPV4TRPM8KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4061124-A1 | TRPV4 RECEPTOR LIGANDS | University of Utah Research Foundation (US) | 2022-09-28 | — | — | EP | disclosed |