Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 7/20 | 0.49 |
| ▸ | TYK2 | P29597 | 5/20 | 0.39 |
| ▸ | EGFR | P00533 | 5/20 | 0.38 |
| ▸ | BTK | Q06187 | 5/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14930559 | 1.00 | SYK (0.49) | SYKTYK2EGFRBTKFER | |
| SCHEMBL16976718 | 0.93 | SYK (0.51) | SYKTYK2EGFRBTKFER | |
| SCHEMBL1992464 | 0.90 | SYK (0.53) | SYKTYK2EGFRBTKFER | |
| SCHEMBL12640991 | 0.88 | SYK (0.47) | SYKTYK2EGFRBTKFER | |
| SCHEMBL21032280 | 0.86 | SYK (0.56) | SYKTYK2EGFRBTKFER | |
| SCHEMBL1991374 | 0.83 | SYK (0.59) | SYKTYK2EGFRBTKFER | |
| SCHEMBL1988427 | 0.83 | SYK (0.51) | SYKTYK2EGFRBTKFER | |
| SCHEMBL25401343 | 0.81 | SYK (0.41) | SYKTYK2EGFRBTKJAK2 | |
| SCHEMBL1988466 | 0.81 | CDK1 (0.39) | SYKBTKFERJAK2 | |
| SCHEMBL1991021 | 0.80 | BTK (0.50) | SYKEGFRBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220306634-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | TAKEDA SAN DIEGO, INC. | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220306634-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | SYK, ZAP70, LYN | SYK 1/4885TYK2 13/4885EGFR 117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.