Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.49 |
| ▸ | PLK1 | P53350 | 2/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28847156 | 1.00 | MAPT (0.54) | MAPTPKML3MBTL1PTPN1PLK1 | |
| SCHEMBL29950353 | 0.90 | SGMS2 (0.58) | MAPTPKML3MBTL1PTPN1SGMS2 | |
| SCHEMBL28847163 | 0.90 | SGMS2 (0.58) | MAPTPKML3MBTL1PTPN1SGMS2 | |
| SCHEMBL28847154 | 0.82 | MAPK1 (0.53) | MAPTSGMS2MEN1POLBKMT2A | |
| SCHEMBL28847223 | 0.80 | PTPN1 (0.50) | MAPTPTPN1PLK1MEN1KMT2A | |
| SCHEMBL29950308 | 0.79 | MAPT (0.52) | MAPTPKML3MBTL1PTPN1SGMS2 | |
| SCHEMBL29950288 | 0.75 | SGMS2 (0.50) | MAPTPKML3MBTL1PTPN1SGMS2 | |
| SCHEMBL27891628 | 0.74 | PLK1 (0.59) | PTPN1PLK1CREBBPNR1H4GAA | |
| SCHEMBL27891629 | 0.74 | PLK1 (0.59) | PTPN1PLK1CREBBPNR1H4GAA | |
| SCHEMBL28304118 | 0.73 | POLB (0.53) | MAPTPTPN1SGMS2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109836378-B | Sphingomyelin synthase inhibitor, preparation method and application thereof | 上海华汇拓医药科技有限公司 | 2022-09-30 | — | — | CN | disclosed |