Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.62 |
| ▸ | APP | P05067 | 2/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 5/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | FLT4 | P35916 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28889771 | 1.00 | PDE5A (0.62) | PDE5AAPPEGFRTSHRLMNA | |
| SCHEMBL4089465 | 0.85 | PDE5A (0.69) | PDE5AAPPTSHRLMNAHTT | |
| SCHEMBL3115968 | 0.84 | TSHR (0.72) | PDE5AEGFRTSHRLMNAHTT | |
| SCHEMBL20119612 | 0.78 | EGFR (0.38) | PDE5AAPPEGFRJAK2IGF1R | |
| SCHEMBL3113122 | 0.77 | APP (1.00) | PDE5AAPPEGFRTSHRLMNA | |
| SCHEMBL29388255 | 0.77 | APP (1.00) | PDE5AAPPEGFRTSHRLMNA | |
| SCHEMBL17799807 | 0.75 | APP (0.68) | PDE5AAPPTSHRLMNAHTT | |
| SCHEMBL26746947 | 0.73 | APP (0.65) | PDE5AAPPEGFRTSHRLMNA | |
| SCHEMBL3106597 | 0.73 | APP (0.85) | PDE5AAPPEGFRLMNAALDH1A1 | |
| SCHEMBL28606239 | 0.73 | EGFR (0.76) | PDE5AEGFRTSHRLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115353507-B | Biphenyl pyrazine quinazoline diamine, synthesis, activity and application thereof | 首都医科大学 | 2023-10-20 | — | — | CN | claimed |
| CN-115353507-A | Biphenyl pyrazine quinazoline diamine, synthesis, activity and application thereof | 首都医科大学 | 2022-11-18 | — | — | CN | claimed |
| CN-115353507-B | Biphenyl pyrazine quinazoline diamine, synthesis, activity and application thereof | 首都医科大学 | 2023-10-20 | — | — | CN | disclosed |
| CN-115353507-A | Biphenyl pyrazine quinazoline diamine, synthesis, activity and application thereof | 首都医科大学 | 2022-11-18 | — | — | CN | disclosed |