SCHEMBL29953452

SCHEMBL29953452

Nc1c(C=O)nc2ccccn12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 1/20 0.54
PTGS2 P35354 1/20 0.54
KDM4E B2RXH2 5/20 0.47
MAPT P10636 2/20 0.47
NPSR1 Q6W5P4 2/20 0.47
ALDH1A1 P00352 11/20 0.47
NPC1 O15118 4/20 0.47
GAA P10253 4/20 0.47
GLA P06280 3/20 0.47
HPGD P15428 2/20 0.47
CASP1 P29466 1/20 0.47
CASP7 P55210 1/20 0.47
HSD17B10 Q99714 1/20 0.47
RAB9A P51151 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.43
HTR6 P50406 3/20 0.43
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
HSP90AA1 P07900 1/20 0.42
HSP90AB1 P08238 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3861933 0.79 ALDH1A1 (0.51) PTGS1PTGS2KDM4EMAPTNPSR1
SCHEMBL13456146 0.79 KDM4E (0.47) PTGS1PTGS2KDM4EMAPTNPSR1
SCHEMBL22519132 0.79 KDM4E (0.55) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL9925517 0.79 KDM4E (0.47) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL870880 0.79 ALDH1A1 (0.55) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL28570789 0.76 HSP90AA1 (0.47) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL890634 0.75 MAPT (0.55) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL13144230 0.75 ALDH1A1 (0.44) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL31423761 0.75 HSD17B10 (0.50) KDM4EMAPTNPSR1ALDH1A1NPC1
SCHEMBL9925518 0.73 KDM4E (0.47) KDM4EMAPTNPSR1ALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed