Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | FBP1 | P09467 | 3/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PLCG2 | P16885 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22806895 | 0.87 | CYP19A1 (0.46) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL3008832 | 0.87 | CYP19A1 (0.46) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL3009578 | 0.85 | PPARG (0.55) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL30224953 | 0.85 | CYP19A1 (0.44) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL31022445 | 0.84 | CYP19A1 (0.43) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL29205700 | 0.82 | CYP19A1 (0.41) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL29205659 | 0.82 | CYP19A1 (0.41) | CYP19A1FBP1NPC1KMT2APPARG | |
| SCHEMBL30183195 | 0.82 | CYP19A1 (0.41) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL31022480 | 0.81 | CYP19A1 (0.41) | CYP19A1FBP1APEX1DHODHNPC1 | |
| SCHEMBL27237628 | 0.81 | FBP1 (0.41) | CYP19A1FBP1APEX1DHODHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3971185-B1 | METHOD FOR PREPARING INDOLE OR INDAZOLE COMPOUND | LG CHEMICAL LTD (KR) | 2024-04-17 | — | — | EP | disclosed |
| CN-114096534-B | Process for preparing indole or indazole compounds | 株式会社LG化学 | 2024-01-02 | — | — | CN | disclosed |
| EP-3971185-A1 | METHOD FOR PREPARING INDOLE OR INDAZOLE COMPOUND | LG Chem, Ltd. (KR) | 2022-03-23 | — | — | EP | disclosed |
| CN-114096534-A | Process for preparing indole or indazole compounds | 株式会社LG化学 | 2022-02-25 | — | — | CN | disclosed |
| WO-2020256432-A1 | METHOD FOR PREPARING INDOLE OR INDAZOLE COMPOUND | 주식회사 엘지화학 | 2020-12-24 | — | — | WO | disclosed |
| EP-2178870-B1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG CHEMICAL LTD (KR) | 2018-09-19 | — | — | EP | disclosed |
| US-9000028-B2 | Indole and indazole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2015-04-07 | — | — | US | disclosed |
| CN-101784543-B | Indole and indazole compounds as inhibitors of cellular necrosis | LG LIFE SCIENCES LTD | 2013-10-16 | — | — | CN | disclosed |
| US-20130237532-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2013-09-12 | — | — | US | disclosed |
| US-8436038-B2 | Indole and indazole compounds as an inhibitor of cellular necrosis | LG LIFE SCIENCES LTD. (KR) | 2013-05-07 | — | — | US | disclosed |
| US-20100197673-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD (KR) | 2010-08-05 | — | — | US | disclosed |
| CN-101784543-A | Indole and indazole compounds as inhibitors of cellular necrosis | LG LIFE SCIENCES LTD | 2010-07-21 | — | — | CN | disclosed |
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130237532-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | IDO1, IDO2, NFATC1 | CYP19A1 2038/4885FBP1 1304/4885APEX1 1552/4885 |
| US-20100197673-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | IDO1, IDO2, NFATC1 | CYP19A1 2038/4885FBP1 1304/4885APEX1 1552/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.