SCHEMBL29953853

SCHEMBL29953853

O=Cc1c[nH]c2cccc(Br)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 1.00
PIM1 P11309 3/20 0.57
PIM3 Q86V86 3/20 0.57
PIM2 Q9P1W9 2/20 0.57
IMPDH2 P12268 1/20 0.52
CLK1 P49759 2/20 0.40
CDK5 Q00535 1/20 0.40
CDK5R1 Q15078 1/20 0.40
TRIM24 O15164 1/20 0.39
TRIM33 Q9UPN9 1/20 0.39
SLC6A4 P31645 1/20 0.38
FGFR1 P11362 1/20 0.37
FGFR2 P21802 1/20 0.37
FGFR3 P22607 1/20 0.37
AHR P35869 1/20 0.37
HTR1D P28221 1/20 0.37
HTR1B P28222 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL644301 1.00 CYP2A6 (1.00) CYP2A6PIM1PIM3PIM2IMPDH2
SCHEMBL29957539 0.85 CYP2A6 (0.74) CYP2A6PIM1PIM3PIM2IMPDH2
SCHEMBL29952428 0.82 CYP2A6 (0.70) CYP2A6PIM1PIM3PIM2IMPDH2
SCHEMBL248842 0.79 CYP2A6 (0.66) CYP2A6PIM1PIM3PIM2IMPDH2
SCHEMBL29408411 0.79 CYP2A6 (0.66) CYP2A6PIM1PIM3PIM2IMPDH2
SCHEMBL3558026 0.78 CYP2A6 (0.64) CYP2A6PIM1PIM3PIM2
SCHEMBL31448012 0.78 CYP2A6 (0.64) CYP2A6PIM1PIM3PIM2
SCHEMBL3558032 0.78 CYP2A6 (0.64) CYP2A6PIM1PIM3PIM2
SCHEMBL1092485 0.78 CYP2A6 (0.64) CYP2A6PIM1PIM3PIM2IMPDH2
SCHEMBL1337252 0.78 CYP2A6 (0.64) CYP2A6PIM1PIM3PIM2IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119731161-A Lysergic acid derivatives and methods 佛罗里达州立大学研究基金会有限公司 2025-03-28 CN disclosed
EP-4337635-A1 VINYL ISOCYANIDE COMPOUNDS AS ANTIBACTERIAL AGENTS University of Leicester (GB) 2024-03-20 EP disclosed
WO-2023250399-A1 TREX1 INHIBITORS AND USES THEREOF TEMPEST THERAPEUTICS, INC. (US) 2023-12-28 WO disclosed
WO-2022238694-A1 VINYL ISOCYANIDE COMPOUNDS AS ANTIBACTERIAL AGENTS THE UNIVERSITY OF BATH (GB) 2022-11-17 WO disclosed
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed