SCHEMBL29954640

SCHEMBL29954640

Cc1nccc(C=O)c1Cl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.45
CCR5 P51681 1/20 0.45
CCR8 P51685 1/20 0.45
ALDH1A1 P00352 5/20 0.37
LMNA P02545 2/20 0.37
TSHR P16473 1/20 0.35
TRIM24 O15164 1/20 0.35
TRIM33 Q9UPN9 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
TDP1 Q9NUW8 3/20 0.33
KMT2A Q03164 5/20 0.33
MEN1 O00255 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
KDM4E B2RXH2 1/20 0.33
MAPT P10636 1/20 0.33
MPI P34949 1/20 0.33
CYP2A6 P11509 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30529332 0.80 CCR1 (0.50) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL748190 0.80 CCR1 (0.50) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL4796219 0.78 CCR1 (0.54) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL29953596 0.77 CCR1 (0.47) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL737167 0.77 CCR1 (0.47) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL19641190 0.76 CCR1 (0.42) CCR1CCR5CCR8ALDH1A1TSHR
SCHEMBL17984975 0.75 CCR1 (0.45) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL19139612 0.75 CCR1 (0.45) CCR1CCR5CCR8LMNATRIM24
SCHEMBL28868517 0.75 TRIM24 (0.53) CCR1CCR5CCR8ALDH1A1LMNA
SCHEMBL2894661 0.75 CCR1 (0.45) CCR1CCR5CCR8ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed