⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10594794 | 0.85 | SMN1; SMN2 (0.35) | — | |
| SCHEMBL28257017 | 0.84 | KDM4E (0.39) | — | |
| SCHEMBL8927705 | 0.81 | SMN1; SMN2 (0.33) | — | |
| SCHEMBL7411217 | 0.80 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL9074125 | 0.79 | SMN1; SMN2 (0.44) | — | |
| SCHEMBL967608 | 0.78 | — | — | |
| SCHEMBL8698130 | 0.78 | — | — | |
| SCHEMBL11527838 | 0.77 | TSHR (0.47) | — | |
| SCHEMBL28220066 | 0.77 | SMN1; SMN2 (0.43) | — | |
| Ammonia Solution, Strong SCHEMBL9998724 | 0.77 | SMN1; SMN2 (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107106524-A | Methods for treating protozoal infections | 尼奥酷里私人有限公司 | 2017-08-29 | — | — | CN | claimed |
| CN-105753965-A | Conjugate Based Systems For Controlled Drug Delivery | 斯马特塞尔斯公司 | 2016-07-13 | — | — | CN | disclosed |
| EP-2776403-A1 | 2,5-DIOXOIMIDAZOLIDIN-1-YL-3-PHENYLUREA DERIVATIVES AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2014-09-17 | — | — | EP | disclosed |
| WO-2013071203-A1 | 2,5-DIOXOIMIDAZOLIDIN-1-YL-3-PHENYLUREA DERIVATIVES AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS | ALLERGAN, INC. (US) | 2013-05-16 | — | — | WO | disclosed |
| US-7786156-B2 | Synthesis methods and intermediates for the manufacture of Rizatriptan | RATIOPHARM GMBH (DE) | 2010-08-31 | — | — | US | disclosed |
| EP-1751104-B1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | RATIOPHARM GMBH (DE) | 2010-03-24 | — | — | EP | disclosed |
| EP-1532134-B1 | NOVEL THIOPHENE ACYL HYDRAZINO DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS MEDICINES, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE | AVENTIS PHARMA SA (FR) | 2008-06-04 | — | — | EP | disclosed |
| US-20070123711-A1 | Synthesis methods and intermediates for the manufacture of rizatriptan | RATIOPHARM GMBH (DE) | 2007-05-31 | — | — | US | disclosed |
| EP-1751104-A1 | SYNTHESIS METHODS AND INTERMEDIATES FOR THE MANUFACTURE OF RIZATRIPTAN | ratiopharm GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| US-20050221990-A1 | Novel benzohydrazide derivatives as herbicides and desiccant compositions contaning them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 2005-10-06 | — | — | US | disclosed |
| US-4463015-A | Aryl substituted 7-oxabicycloheptane compounds, useful in inhibiting platelet aggregation | E. R. SQUIBB & SONS, INC. (US) | 1984-07-31 | — | — | US | disclosed |
| WO-1984000754-A1 | ARYL SUBSTITUTED 7-OXABICYCLOHEPTANE COMPOUNDS | SQUIBB & SONS INC (US) | 1984-03-01 | — | — | WO | disclosed |
| US-4418076-A | 7-Oxabicycloheptane hydrazone prostaglandin analogs useful in treating thrombolytic diseases | E. R. SQUIBB & SONS, INC. (US) | 1983-11-29 | — | — | US | disclosed |
| EP-0065366-A2 | Reagents for graft copolymers | The Malaysian Rubber Producers' Research Association (GB) | 1982-11-24 | — | — | EP | disclosed |
| US-4160088-A | HALOGENATION OF KETONE, ALKANOL, HYDROLYSIS | GENERAL ELECTRIC COMPANY (US) | 1979-07-03 | — | — | US | disclosed |
| US-4158094-A | BLOWING AGENTS | GENERAL ELECTRIC COMPANY (US) | 1979-06-12 | — | — | US | disclosed |
| US-4097671-A | 5-PHENYL-3,6-DIHYDRO-1,3,4-OXADIAZIN-2-ONE, THERMOPLASTIC POLYMER BLOWING AGENT | GENERAL ELECTRIC COMPANY (US) | 1978-06-27 | — | — | US | disclosed |
| US-4070355-A | CNS DEPRESSANTS, SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | E. R. SQUIBB & SONS, INC. (US) | 1978-01-24 | — | — | US | disclosed |
| US-4033947-A | CNS DEPRESSANTS, SEDATIVES, MUSCLE RELAXANTS | E. R. SQUIBB & SONS, INC. (US) | 1977-07-05 | — | — | US | disclosed |
| US-3946064-A | EXPANDING POLYMERS | UNIROYAL, INC. (US) | 1976-03-23 | — | — | US | disclosed |