SCHEMBL29956271

SCHEMBL29956271

O=Cc1c[nH]c2c(Cl)nccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRIM24 O15164 1/20 0.49
TRIM33 Q9UPN9 1/20 0.49
KMT2A Q03164 1/20 0.49
PIM3 Q86V86 9/20 0.44
PIM1 P11309 7/20 0.44
PIM2 Q9P1W9 2/20 0.44
CYP2A6 P11509 2/20 0.42
IMPDH2 P12268 1/20 0.42
CCR1 P32246 1/20 0.40
CCR5 P51681 1/20 0.40
CCR8 P51685 1/20 0.40
DRD2 P14416 1/20 0.40
DRD4 P21917 1/20 0.40
DRD3 P35462 1/20 0.40
CCNT1 O60563 1/20 0.39
CDK9 P50750 1/20 0.39
HASPIN Q8TF76 1/20 0.39
KDM5A P29375 1/20 0.38
KDM4C Q9H3R0 1/20 0.38
RXFP1 Q9HBX9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29952712 0.81 PIM3 (0.48) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL29954304 0.81 TRIM24 (0.47) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL29954589 0.81 TRIM24 (0.56) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL12693836 0.81 KMT2A (0.47) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL29951661 0.81 KMT2A (0.47) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL13909727 0.81 PIM3 (0.48) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL29954104 0.77 KMT2A (0.44) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL29957087 0.77 TRIM24 (0.44) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL29956847 0.77 TRIM24 (0.47) TRIM24TRIM33KMT2APIM3PIM1
SCHEMBL14519078 0.76 PIM3 (0.65) TRIM24TRIM33KMT2APIM3PIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed