Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6687035 | 0.81 | — | — | |
| SCHEMBL7347720 | 0.74 | ALDH1A1 (0.38) | HPGDKMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL7335663 | 0.74 | ALDH1A1 (0.38) | HPGDKMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL901643 | 0.73 | ALDH1A1 (0.33) | HPGDKMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL343088 | 0.73 | ALDH1A1 (0.33) | HPGDKMT2AHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL30918323 | 0.69 | EPHX2 (0.42) | HPGDKMT2AALDH1A1TSHRHSD17B10 | |
| SCHEMBL6039423 | 0.69 | — | — | |
| Water SCHEMBL2016655 | 0.69 | PSEN1 (0.32) | SMN1; SMN2LMNAUSP2 | |
| Acetic Acid SCHEMBL1686096 | 0.67 | KMT2A (0.47) | HPGDKMT2AHTTALDH1A1SMN1; SMN2 | |
| Acetonitrile SCHEMBL27552278 | 0.67 | ALDH1A1 (0.45) | HPGDKMT2AALDH1A1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2048972-B1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF LYCOPENE FOR SKIN AND HAIR | INDENA SPA (IT) | 2018-10-10 | — | — | EP | disclosed |
| CN-101500436-B | Stable and bioavailable compositions of isomers of lycopene for skin and hair | 因德纳有限公司 | 2017-04-12 | — | — | CN | disclosed |
| EP-2051595-B1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF CAROTENOIDS FOR SKIN AND HAIR | NESTEC SA (CH) | 2015-11-11 | — | — | EP | disclosed |
| US-20150258038-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF CAROTENOIDS FOR SKIN AND HAIR | NESTEC S.A. (CH) | 2015-09-17 | — | — | US | disclosed |
| US-9125430-B2 | Stable and bioavailable compositions of isomers of carotenoids for skin and hair | NESTEC S.A. (CH) | 2015-09-08 | — | — | US | disclosed |
| US-8568806-B2 | Stable and bioavailable compositions of isomers of lycopene for skin and hair | INDENA, S.P.A. (IT) | 2013-10-29 | — | — | US | disclosed |
| US-8216619-B2 | Stable and bioavailable compositions of isomers of carotenoids for skin and hair | INDENA S.P.A. (IT) | 2012-07-10 | — | — | US | disclosed |
| US-20100190867-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF LYCOPENE FOR SKIN AND HAIR | INDENA S.P.A. (IT) | 2010-07-29 | — | — | US | disclosed |
| US-20100183537-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF CAROTENOIDS FOR SKIN AND HAIR | NESTEC S.A. (CH) | 2010-07-22 | — | — | US | disclosed |
| EP-2051595-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF CAROTENOIDS FOR SKIN AND HAIR | Nestec S.A. (CH) | 2009-04-29 | — | — | EP | disclosed |
| EP-2048972-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF LYCOPENE FOR SKIN AND HAIR | INDENA S.p.A. (IT) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017455-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF CAROTENOIDS FOR SKIN AND HAIR | NESTEC S.A. (CH) | 2008-02-14 | — | — | WO | disclosed |
| WO-2008017401-A1 | STABLE AND BIOAVAILABLE COMPOSITIONS OF ISOMERS OF LYCOPENE FOR SKIN AND HAIR | INDENA S.P.A. (IT) | 2008-02-14 | — | — | WO | disclosed |
| US-20080038391-A1 | Stable and bioavailable compositions of isomers of carotenoids for skin and hair | INDENA S.P.A.. | 2008-02-14 | — | — | US | disclosed |
| EP-1886584-A1 | Stable and bioavailable compositions of isomers of lycopene for skin and hair | Indena S.P.A. (IT) | 2008-02-13 | — | — | EP | disclosed |