Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rocuronium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.57 |
| ▸ | SLC47A2 | Q86VL8 | 1/20 | 0.57 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | RAD52 | P43351 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rocuronium SCHEMBL3829410 | 1.00 | KCNH2 (1.00) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL13790944 | 1.00 | KCNH2 (1.00) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL13875772 | 1.00 | KCNH2 (1.00) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL3823993 | 1.00 | KCNH2 (1.00) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL3986752 | 0.99 | KCNH2 (0.99) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL3835255 | 0.99 | KCNH2 (0.99) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL3986751 | 0.99 | KCNH2 (0.99) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL21623717 | 0.99 | KCNH2 (0.99) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL41320 | 0.99 | KCNH2 (0.99) | KCNH2AGTR1HRH3SLC22A2SLC47A2 | |
| Rocuronium SCHEMBL1036090 | 0.99 | KCNH2 (0.99) | KCNH2AGTR1HRH3SLC22A2SLC47A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3177 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12635940-B2 | Closed-loop drug infusion system with synergic control | UNIVERSIDAD POLITÉCNICA DE MADRID FUNDACION PARA LA INVESTIGACIÓN E INNOVACIÓN BIOMÉDICA (ES) | 2026-05-26 | — | — | US | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| EP-4719552-A1 | INDUCTION OF GENERAL ANESTHESIA IN ADULTS UNDERGOING ELECTIVE SURGERY | Xizang Haisco Pharmaceutical Co., Ltd. (CN) | 2026-04-08 | — | — | EP | claimed |
| EP-4076560-B1 | SURFACE MODIFYING COATING FOR MEDICAL DEVICES | HOSPIRA INC (US) | 2026-04-01 | — | — | EP | claimed |
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4687914-A1 | A ROOM-TEMPERATURE STABLE, UNBUFFERED FORMULATION OF ROCURONIUM BROMIDE INJECTION FOR INTRAVENOUS ADMINISTRATION AND A METHOD THEREOF | Maiva Pharma Private Limited (IN) | 2026-02-11 | — | — | EP | claimed |
| US-20260000678-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTING, SUPPRESSING, OR TREATING SYMPTOM ASSOCIATED WITH PSEUDO-ALLERGIC REACTION | TAKASAKI UNIV OF HEALTH AND WELFARE (JP) | 2026-01-01 | — | — | US | claimed |
| EP-4656660-A1 | ALFA-, BETA-, AND GAMMA- CYCLODEXTRIN DERIVATIVES DECORATED WITH (2-MERCAPTOETHYL)PHOSPHONIC ACID BRANCHES, SYNTHESIS AND APPLICATIONS | Universidad de Almeria (ES) | 2025-12-03 | — | — | EP | claimed |
| US-12472304-B2 | Adaptive neuro-fuzzy inference system for closed loop total intravenous anesthesia management | SMARTTIVA INC (US) | 2025-11-18 | — | — | US | claimed |
| US-20250339621-A1 | ROCURONIUM IN PREFILLED SYRINGES | BRAUN MELSUNGEN AG (DE) | 2025-11-06 | — | — | US | claimed |
| EP-1259550-A1 | 6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK | Akzo Nobel N.V. (NL) | 2002-11-27 | — | — | EP | claimed |
| WO-2002064635-A1 | 2-ALKYLATED-CYCLODEXTRIN DERIVATIVES: REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK | AKZO NOBEL N.V. (NL) | 2002-08-22 | — | — | WO | claimed |
| EP-1131062-A4 | INJECTABLE PROPOFOL FORMULATIONS | VETERINARY RES ASSOCIATES INC (US) | 2002-07-03 | — | — | EP | claimed |
| EP-1210090-A2 | USE OF CHEMICAL CHELATORS AS REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK | Akzo Nobel N.V. (NL) | 2002-06-05 | — | — | EP | claimed |
| EP-1131062-A1 | INJECTABLE PROPOFOL FORMULATIONS | Veterinary Research Associates, Inc. (US) | 2001-09-12 | — | — | EP | claimed |
| WO-2001040316-A1 | 6-MERCAPTO-CYCLODEXTRIN DERIVATIVES: REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK | AKZO NOBEL N.V. (NL) | 2001-06-07 | — | — | WO | claimed |
| WO-2001012202-A2 | USE OF CHEMICAL CHELATORS AS REVERSAL AGENTS FOR DRUG-INDUCED NEUROMUSCULAR BLOCK | AKZO NOBEL N.V. (NL) | 2001-02-22 | — | — | WO | claimed |
| US-6025399-A | WITH A NON DEPOLARIZING MUSCLE RELAXANT, FACILITATING TRACHEAL INTUBATION OR FOR PROVIDING MUSCULAR RELAXATION FOR SHORT LASTING SURGICAL PROCEDURES. | MONTEFIORE MEDICAL CENTER (US) | 2000-02-15 | — | — | US | claimed |
| WO-2000006142-A1 | INJECTABLE PROPOFOL FORMULATIONS | VETERINARY RESEARCH ASSOCIATES (US) | 2000-02-10 | — | — | WO | claimed |
| US-5962536-A | USING N-METHYLPYRROLIDONE OR 2-PYRROLIDONE AS SOLVENT | VETERINARY RESEARCH ASSOCIATES, INC. | 1999-10-05 | — | — | US | claimed |